Archive for the tag: Mystery

Behind the Mystery: Myasthenia Gravis

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Myasthenia gravis (MG) means grave or serious muscle weakness, which is what patients experience with this rare, autoimmune disease. The hallmark symptom is muscle weakness that worsens after periods of activity and improves after periods of rest.

University of South Florida (USF) Health Department of Neurology physician Dr. Niraja Suresh details the disease spectrum, how a diagnosis is obtained, and how to manage the condition.

In November 2020, argenx, a global immunology company, premiered the first-ever MG documentary film series called, “A Mystery to Me.” The docuseries illustrated the perseverance of three individuals as they navigate the challenges of living with MG and adapt their lives to accommodate the debilitating illness. Teresa, who was featured in the docuseries, was a busy mom, wife, and new business owner when she started to experience extreme weakness in her arms and legs. It took almost 2 years of seeing multiple doctors for her to get diagnosed. She shares her advice for other patients that anyone can relate to.

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Mystery illness outbreak in Wuhan, China

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An unknown strain of pneumonia has been making people ill in Wuhan, China. 44 people have been infected with the unidentified virus, with 11 of them in a serious condition. The local government and health authorities have been able to rule out Avian flu, influenza and adenovirus infection.Many of the patients worked at a seafood market that also traded in live animals like rabbits and birds which has prompted some concerns about a return of the deadly 2002 Sars virus. While Sars hasn’t yet been ruled out, there is no evidence of human-to-human transmission and no medical personnel have become infected.

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Well, may be. Peer review required, but an interesting possibility.
Detectan el SARS-CoV-2 en aguas residuales recogidas en Barcelona el 12 marzo de 2019 (Universitit de Barcelona)

https://www.ub.edu/web/ub/es/menu_eines/noticies/2020/06/042.html

SARS-CoV-2 detected in Barcelona water study from March 2019

https://www.catalannews.com/society-science/item/sars-cov-2-detected-in-barcelona-water-study-from-march-2019

Covid-19 was in Spanish sewage as early as MARCH 2019, study claims

https://www.rt.com/news/493085-covid-spain-march-2019-sewage/

Coronavirus traces found in March 2019 sewage sample, Spanish study shows

https://www.reuters.com/article/us-health-coronavirus-spain-science/coronavirus-traces-found-in-march-2019-sewage-sample-spanish-study-shows-idUSKBN23X2HQ

Sentinel surveillance of SARS-CoV-2 in wastewater anticipates the occurrence of COVID-19 cases

https://www.medrxiv.org/content/10.1101/2020.06.13.20129627v1.full.pdf

December 2019, COVID-19 originated in Wuhan, China

Late January 2020, detected in France

February 25th first detected in Barcelona

Sewage in Barcelona

Frozen archival samples

January 15 to March 4, 2020 increasing levels

March 4 to May 4 2020, highest levels

Some uncharacterized influenza cases may have masked COVID-19 cases in the 2019-2020 season

Therefore January 2018 to December 2019 samples analysed

All samples tested negative for the presence of SARS-CoV-2 genomes with the exception of March 12, 2019,

The levels of SARS-CoV-2 were low but were positive

Indicates circulation of the virus in Barcelona long before the report of any COVID-19 case worldwide

A significant proportion of undiagnosed and asymptomatic carriers shed SARS- CoV-2 in stool
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